SYNTHETIC STUDIES TOWARDS CYCLIC-PEPTIDES - CONCISE SYNTHESIS OF THIAZOLINE AND THIAZOLE CONTAINING AMINO-ACIDS

被引：92

作者：

NORTH, M ^{[1
]}

PATTENDEN, G ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND

来源：

TETRAHEDRON | 1990年 / 46卷 / 24期

关键词：

D O I：

10.1016/S0040-4020(01)81482-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Concise and efficient syntheses of optically pure thiazoline and thiazole containing amino acids of the constitution (26) and (27), based on simple condensation reactions between cysteine esters and N-protected imino ethers (22) and (25) derived from chiral amino acids, are described. The synthetic procedures are compatible with a range of amino acid side chains and protecting groups, and allow the preparation of a variety of small optically pure peptides i.e. (32) and (34) suitable for elaboration to naturally occurring cyclic peptides e.g. the lissoclinamides (3) and (4). © 1990.

引用

页码：8267 / 8290

页数：24

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