MODULATION OF HEPATIC FIBROGENESIS BY ANTIOXIDANTS

被引：13

作者：

POLI, G

PAROLA, M

LEONARDUZZI, G

PINZANI, M

机构：

[1] UNIV TURIN, DIPARTIMENTO MED & ONCOL SPERIMENTALE, I-10124 TURIN, ITALY

[2] UNIV FIRENZE, IST CLIN MED 2, TURIN, ITALY

[3] CNR, CTR IMMUNOGENET & ONCOL SPERIMENTALE, TURIN, ITALY

来源：

MOLECULAR ASPECTS OF MEDICINE | 1993年 / 14卷 / 03期

关键词：

D O I：

10.1016/0098-2997(93)90013-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The oxidative damage of liver tissue appears to favour a fibrogenic process, through the stimulation of TGFbeta1 and procollagen gene expression. The latter effect has been also showed by a well defined end-product of lipid peroxida-tion, 4-hydroxy-2,3-nonenal in human Ito cell culture. ''In vivo'' and ''in vitro'' data give evidence of a strong down modulation of TGFbeta1 and collagen expression afforded by supplementation with different antioxidant molecules.

引用

页码：259 / 264

页数：6

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