MODULATION OF HEPATIC FIBROGENESIS BY ANTIOXIDANTS

被引：13
|
作者：
POLI, G
PAROLA, M
LEONARDUZZI, G
PINZANI, M
机构：
[1] UNIV TURIN, DIPARTIMENTO MED & ONCOL SPERIMENTALE, I-10124 TURIN, ITALY
[2] UNIV FIRENZE, IST CLIN MED 2, TURIN, ITALY
[3] CNR, CTR IMMUNOGENET & ONCOL SPERIMENTALE, TURIN, ITALY
来源：
MOLECULAR ASPECTS OF MEDICINE | 1993年 / 14卷 / 03期
关键词：
D O I：
10.1016/0098-2997(93)90013-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The oxidative damage of liver tissue appears to favour a fibrogenic process, through the stimulation of TGFbeta1 and procollagen gene expression. The latter effect has been also showed by a well defined end-product of lipid peroxida-tion, 4-hydroxy-2,3-nonenal in human Ito cell culture. ''In vivo'' and ''in vitro'' data give evidence of a strong down modulation of TGFbeta1 and collagen expression afforded by supplementation with different antioxidant molecules.
引用
收藏
页码：259 / 264
页数：6
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