SYNTHESIS OF OCTACARBOXYTETRA(2,3-PYRAZINO)PORPHYRAZINE - NOVEL WATER-SOLUBLE PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY

被引：47
|
作者：
KUDREVICH, SV
GALPERN, MG
VANLIER, JE
机构：
[1] UNIV SHERBROOKE,FAC MED,MRC,RADIAT SCI GRP,SHERBROOKE J1H 5N4,PQ,CANADA
[2] MOSCOW ORGAN INTERMED & DYE RES INST,MOSCOW 103787,RUSSIA
来源：
SYNTHESIS-STUTTGART | 1994年 / 08期
关键词：
PHTHALOCYANINE; AZA ANALOG; OCTACARBOXY DERIVATIVE; PHOTODYNAMIC THERAPY;
D O I：
10.1055/s-1994-25571
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The condensation of 2,3-dicyano-5,6-diethoxycarbonylpyrazine with a metal salt affords tetra-2,3-(5,6-diethoxycarbonylpyrazino)porphyrazine, which upon mild hydrolysis yields novel water-soluble metal complexes of tetra-2,3-(5,6-dicarboxypyrazino)porphyrazine. These octaaza analogs of phthalocyanine have potential applications in the field of photodynamic therapy of cancer.
引用
收藏
页码：779 / 781
页数：3
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