A RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND-STUDY OF DANAZOL IN HEMOPHILIA-A

被引：0
|
作者：
MEHTA, J [1 ]
SINGHAL, S [1 ]
KAMATH, MV [1 ]
MEHTA, BC [1 ]
机构：
[1] KING EDWARD MEM HOSP,DEPT HEMATOL,BOMBAY,INDIA
来源：
ACTA HAEMATOLOGICA | 1992年 / 88卷 / 01期
关键词：
DANAZOL; FACTOR VIII C; HEMOPHILIA-A;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A randomized double-blind placebo-controlled crossover trial of danazol was carried out in 19 cases of hemophilia A. Danazol was given for 3 months at a dose of 150 mg/day to patients under 15 years of age, and 300 mg/day to older patients. The basal factor VIII:C level was 8.3 +/- 5.6% (mean +/- SD), and after 3 months of danazol treatment was 15.3 +/- 11.0% (p = 0.02). Six patients (basal factor VIII:C 2-22%) showed a 1.36- to 2.87-fold elevation of factor VIII:C levels after danazol. 0/2, 1/4 and 5/13 cases of severe, moderate and mild disease, respectively, responded. Decreases in the number of bleeding episodes and cryoprecipitate requirement were seen in the responders. No adverse reactions to danazol were encountered. Danazol appears to raise the factor VIII:C levels in selected cases of hemophilia A.
引用
收藏
页码：14 / 16
页数：3
相关论文
共 50 条
  • [21] TERLIPRESSIN IN BLEEDING ESOPHAGEAL-VARICES - A PLACEBO-CONTROLLED, DOUBLE-BLIND-STUDY
    WALKER, S
    STIEHL, A
    RAEDSCH, R
    KOMMERELL, B
    HEPATOLOGY, 1986, 6 (01) : 112 - 115
  • [22] PLACEBO-CONTROLLED, DOUBLE-BLIND-STUDY OF HEMODILUTION IN PERIPHERAL ARTERIAL-DISEASE
    ERNST, E
    MATRAI, A
    KOLLAR, L
    LANCET, 1987, 1 (8548): : 1449 - 1451
  • [23] SYNTHETIC HUMAN CALCITONIN IN POSTMENOPAUSAL OSTEOPOROSIS - A PLACEBO-CONTROLLED, DOUBLE-BLIND-STUDY
    LJUNGHALL, S
    GARDSELL, P
    JOHNELL, O
    LARSSON, K
    LINDH, E
    OBRANT, K
    SERNBO, I
    CALCIFIED TISSUE INTERNATIONAL, 1991, 49 (01) : 17 - 19
  • [24] PLACEBO-CONTROLLED DOUBLE-BLIND-STUDY OF EFFECT OF PHENOXYBENZAMINE IN BENIGN PROSTATIC OBSTRUCTION
    CAINE, M
    PERLBERG, S
    MERETYK, S
    BRITISH JOURNAL OF UROLOGY, 1978, 50 (07): : 551 - 554
  • [25] ACUTE CONTUSIONS - PLACEBO-CONTROLLED DOUBLE-BLIND-STUDY OF THE EFFICACY OF MOBILAT OINTMENT
    BOHMER, D
    MUNCHENER MEDIZINISCHE WOCHENSCHRIFT, 1986, 128 (10): : 176 - 179
  • [26] INDOBUFEN IN THE PREVENTION OF THROMBOEMBOLIC COMPLICATIONS IN PATIENTS WITH HEART-DISEASE - A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND-STUDY
    FORNARO, G
    ROSSI, P
    MANTICA, PG
    CACCIA, ME
    ARALDA, D
    LAVEZZARI, M
    PAMPARANA, F
    MILANESI, G
    CIRCULATION, 1993, 87 (01) : 162 - 164
  • [27] A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND-STUDY EVALUATING THE EFFICACY OF LEUPROLIDE ACETATE DEPOT IN THE TREATMENT OF UTERINE LEIOMYOMATA
    FRIEDMAN, AJ
    HARRISONATLAS, D
    BARBIERI, RL
    BENACERRAF, B
    GLEASON, R
    SCHIFF, I
    FERTILITY AND STERILITY, 1989, 51 (02) : 251 - 256
  • [28] LUPRON DEPOT (LEUPROLIDE ACETATE FOR DEPOT SUSPENSION) IN THE TREATMENT OF ENDOMETRIOSIS - A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND-STUDY
    DLUGI, AM
    MILLER, JD
    KNITTLE, J
    FERTILITY AND STERILITY, 1990, 54 (03) : 419 - 427
  • [29] RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND-STUDY WITH TPA IN ACUTE CORONARY INFARCTION - VENTRICULAR ARRHYTHMIAS AS AN INDICATOR FOR REPERFUSION
    LANGES, K
    SCHOFER, J
    KUCK, KH
    BLEIFELD, W
    MATHEY, DG
    ZEITSCHRIFT FUR KARDIOLOGIE, 1986, 75 : 89 - 89
  • [30] TRANEXAMIC ACID AS PROPHYLAXIS IN HEMOPHILIA - A RANDOMIZED DOUBLE-BLIND-STUDY
    SCHIAVONI, M
    ETTORRE, C
    ANTONCECCHI, S
    CIAVARELLA, N
    SCHANNONG, M
    THROMBOSIS AND HAEMOSTASIS, 1983, 50 (01) : 444 - 444
12345