RELATIONSHIP BETWEEN PARACETAMOL PLASMA-LEVELS AND ITS ANALGESIC EFFECT IN THE RAT

被引：34
|
作者：
GRANADOSSOTO, V
FLORESMURRIETA, FJ
LOPEZMUNOZ, FJ
SALAZAR, LA
VILLARREAL, JE
CASTANEDAHERNANDEZ, G
机构：
[1] INST POLITECN NACL,DEPT FARMACOL & TOXICOL,CTR INVEST & ESTUDIOS AVANZADOS,SECC TERAPEUT EXPTL,MEXICO CITY 14000,DF,MEXICO
[2] UNIV AUTONOMA METROPOLITANA AZCAPOTZALCO,DEPT SISTEMAS BIOL,DIV SCI BIOL & SALUD,MEXICO CITY 13,DF,MEXICO
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 09期
关键词：
D O I：
10.1111/j.2042-7158.1992.tb05511.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The relationship between plasma levels of paracetamol and its analgesic effect was studied in the rat using a model of pain-induced functional impairment (PIFI). Female Wistar rats received an intra-articular injection of 30% uric acid in the knee of the right hind limb, inducing its dysfunction. Animals then received oral paracetamol at doses of 178, 316 or 562 mg kg-1 and the recovery of functionality over time was considered as an expression of analgesia. Paracetamol plasma levels were determined by HPLC. Results showed that there is a direct relationship between paracetamol plasma levels and its analgesic effect that follows a sigmoidal model according to the Hill equation. The PIFI model appears to be a useful tool to establish pharmacokinetic/pharmacodynamic relationships for non-narcotic analgesics.
引用
收藏
页码：741 / 744
页数：4
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