MESANGIAL STRUCTURE AND FUNCTION IN THE REMNANT KIDNEY

被引:25
|
作者
SCHWARTZ, MM
BIDANI, AK
机构
[1] RUSH MED COLL,DEPT PATHOL,CHICAGO,IL 60612
[2] LOYOLA UNIV,SCH MED,DEPT MED,NEPHROL SECT,CHICAGO,IL 60611
关键词
D O I
10.1038/ki.1991.204
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The pathogenetic significance of changes in mesangial structure and function were studied in hypertensive (HT) (BP +/- SD = 173 +/- 23 mm Hg, N = 13) and normotensive (NT) (130 +/- 17 mm Hg, N = 12) WKY rats with 5/6 nephrectomy and compared to sham-operated controls (SHAM) (121 +/- 11 mm Hg, N = 12). Rats were fed a 24% protein diet and studied six to eight weeks after surgery. Acute glomerular necrosis was present in 6/13 HT, 1/12 NT, and 0/12 SHAM, and glomerular sclerosis was seen in 7/13 HT, 4/12 NT, and 0/12 SHAM. HT and NT had glomerular and tubular hypertrophy compared to SHAM (mean glomerular diameter +/- SD. HT = 174 +/- 17-mu and NT = 171 +/- 12 cf. SHAM = 142 +/- 11, P = 0.0012, ANOVA). The fractional mesangial volumes, determined by ultrastructural morphometry, were similar in all groups, but the absolute volumes were increased in the HT and NT (HT = 323 +/- 103-mu-3 x 10(-3) and NT = 335 +/- 75 cf. SHAM = 164 +/- 20, P = 0.01, ANOVA). Mesangial clearance of aggregated rat IgG (AgRalgG) was studied in serial biopsies by immunofluorescence microscopy. Following i.v. injection, mesangial AgRalgG appeared increased in HT and NT over SHAM for four hours, but after 24 hours, the label had disappeared from the mesangium in all groups. We conclude that neither increased mesangial volume nor abnormalities of mesangial clearance of macromolecules plays a role in the pathogenesis of the acute, necrotizing glomerular lesion which was mainly seen in HT rats. On the other hand glomerular sclerosis, seen in both NT and HT rats but not sham controls, may result from more than one mechanism. In the HT rats scarring may result from healing of the acute glomerular lesions. Although we have excluded the mesangial clearance function as a factor in the pathogenesis of glomerular sclerosis, the presence of glomerular scarring in NT rats suggests that the lesions may result from dysfunction of other glomerular cells or unmeasured mesangial cell functions.
引用
收藏
页码:226 / 237
页数:12
相关论文
共 50 条
  • [31] IRON DEPLETION IN THE REMNANT KIDNEY
    NANKIVELL, BJ
    HARRIS, DCH
    NEPHRON, 1995, 70 (03): : 340 - 347
  • [32] ROLE OF ALDOSTERONE IN THE REMNANT KIDNEY
    GREENE, E
    KREN, S
    HOSTETTER, T
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1994, 5 (03): : 541 - 541
  • [33] HYPERMETABOLISM IN REMNANT DOG KIDNEY
    FINE, A
    KIDNEY INTERNATIONAL, 1990, 37 (01) : 527 - 527
  • [34] Predonation Volume of Future Remnant Cortical Kidney Helps Predict Postdonation Renal Function in Live Kidney Donors
    Fananapazir, Ghaneh
    Benzl, Robert
    Corwin, Michael T.
    Chen, Ling-Xin
    Sageshima, Junichiro
    Stewart, Susan L.
    Troppmann, Christoph
    RADIOLOGY, 2018, 288 (01) : 153 - 157
  • [35] MESANGIAL EXPANSION AS A CENTRAL MECHANISM FOR LOSS OF KIDNEY-FUNCTION IN DIABETIC-PATIENTS
    STEFFES, MW
    OSTERBY, R
    CHAVERS, B
    MAUER, SM
    DIABETES, 1989, 38 (09) : 1077 - 1081
  • [36] CFTR structure and function: Is there a role in the kidney?
    Souza-Menezes J.
    Morales M.M.
    Biophysical Reviews, 2009, 1 (1) : 3 - 12
  • [37] ON STRUCTURE AND FUNCTION OF KIDNEY IN EXPERIMENTAL HYPERPARATHYROIDISM
    ENGFELDT, B
    HELANDER, CG
    GRADELL, S
    LAGERGREN, C
    ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA, 1961, 51 : 57 - &
  • [38] TERMINAL COLLECTING DUCT (CD) AND JUXTAMEDULLARY NEPHRON (JMN) FUNCTION IN REMNANT KIDNEY (RK)
    BUERKERT, J
    PRASAD, J
    MARTIN, D
    CHAMBLESS, S
    KLAHR, S
    CLINICAL RESEARCH, 1978, 26 (03): : A459 - A459
  • [39] The structure and function of the kidney of lophius piscatorius
    Marshall, E. K., Jr.
    Grafflin, Allan L.
    BULLETIN OF THE JOHNS HOPKINS HOSPITAL, 1928, 43 : 205 - 235
  • [40] FUNCTION AND STRUCTURE OF PERFUSED BULLFROG KIDNEY
    DEEDS, DG
    SULLIVAN, LP
    FENTON, RA
    TUCKER, JM
    CUPPAGE, FE
    AMERICAN JOURNAL OF PHYSIOLOGY, 1977, 233 (05): : F481 - F490