PARENTAL INFLUENCES ON EXPRESSION OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE, G6PD, IN THE MOUSE - A CASE OF IMPRINTING

Glucose-6-phosphate dehydrogenase (G6PD) activity was measured in blood from heterozygotes for the normal allele G6pda and the low activity allele G6pda-m l Neu. In adult mice lower activity was found in G6pda/G6pda-m l Neu than in the reciprocal heterozygote G6pda-m l Neu/G6pda (the maternal allele being listed first). Thus, either the paternally derived allele was over-expressed or the maternally derived allele was under-expressed. By contrast, in younger mice the difference in G6PD activity in reciprocal crosses was less marked. The findings are interpreted in terms of differential imprinting of maternally and paternally inherited information. The explanation offered for age related differences is that, as a consequence of imprinting, either the paternal X-chromosome is preferentially reactivated, or cells in which the paternally derived allele is active are at a selective advantage, and proliferate better than those in which the maternally inherited allele is active. © 1990, Cambridge University Press. All rights reserved.