Serum homocysteine is associated with polycystic ovarian syndrome in Jordan

被引:15
|
作者
Saadeh, Nesreen [1 ]
Alfaqih, Mahmoud A. [2 ]
Mansour, Haneen [2 ]
Khader, Yousef S. [3 ]
Saadeh, Rami [3 ]
Al-Dwairi, Ahmed [2 ]
Nusier, Mohamad [2 ]
机构
[1] Jordan Univ Sci & Technol, Sch Med, Dept Internal Med, Irbid 22110, Jordan
[2] Jordan Univ Sci & Technol, Sch Med, Dept Physiol & Biochem, M3L0, Irbid 22110, Jordan
[3] Jordan Univ Sci & Technol, Sch Med, Dept Family Med & Publ Hlth, Irbid 22110, Jordan
关键词
polycystic ovarian syndrome; insulin resistance; homocysteine; 5-methyltetrahydrofolate; methylenetetrahydrofolate reductase;
D O I
10.3892/br.2018.1149
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Polycystic ovarian syndrome (PCOS) is a prevalent endocrinopathy among women of a reproductive age. Although not included in the diagnostic criteria, insulin resistance (IR) is a major characteristic of PCOS and may contribute to its development. The exact cause of IR remains unknown but appears to be multifactorial. Changes in the levels of leptin, adiponectin, branched-chain amino acids (BCAAs) and/or homocysteine have been reported in women with PCOS. However, the relative contribution of the aforementioned metabolites to PCOS has not been tested in Jordan. In the present study, 154 women diagnosed with PCOS and 151 normally menstruating women matched by age and body mass index (BMI) were recruited. The levels of leptin, adiponectin, BCAAs, homocysteine and 5-methyltetrahydrofolate (5-MTHF) were measured in the serum of the recruited participants. It was revealed that homocysteine levels were significantly elevated in women with PCOS compared with normally menstruating women (P<0.0001), while 5-MTHF (P=0.024), leptin (P=0.027) and adiponectin (P=0.010) levels were significantly lower. In multivariate analysis, serum homocysteine had the strongest association with PCOS and significantly increased its risk [P<0.0001; odds ratio 1.217; 95% confidence interval (CI) 1.157-1.280]. With an area under the curve of 0.855 (95% CI 0.811-0.898) in receiver operating characteristic analysis, serum homocysteine was determined to be a good predictor for PCOS diagnosis based on Rotterdam guidelines. It was concluded that serum levels of homocysteine are elevated in women with PCOS in Jordan independent of age, BMI, or leptin, adiponectin and BCAAs levels.
引用
收藏
页码:439 / 445
页数:7
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