A Comprehensive Review of Benzo Alpha Pyrene (B[A]P) Toxicology

被引：0

作者：

Agrawal, Sandeep ^{[1
]}

Kaur, Amar Preet ^{[1
]}

Taneja, Kanchan ^{[2
]}

机构：

[1] All India Inst Med Sci, Dept Biochem, New Delhi 110029, India

[2] Chacha Nehru Bal Chikitsalaya, Dept Biochem, New Delhi 110031, India

来源：

RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES | 2018年 / 9卷 / 04期

关键词：

Benzo alpha pyrene (B[a]P); Polycyclic Aromatic Hydrocarbon (PAH); carcinogen; Cytochrome P450;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Benzo Alpha Pyrene (B[a]P) is a prototype Polycyclic Aromatic Hydrocarbon (PAH). It is a well known environmental pollutant and a procarcinogen. It is present ubiquitously in the environment and exposure to B[a]P occurs through air, food, water, skin contact etc. It is metabolized in the body by phase I and phase II reactions and the primary metabolites are non-toxic and easily excretable. A minor fraction of B[a]P is converted to active metabolites which are carcinogenic and adversely affect other systems of the body. This review covers all aspects of B[a]P including sources, exposure, metabolism and toxicity profile.

引用

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页码：1049 / 1058

页数：10

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