MECHANISM OF THE RAPID LETHAL ACTION OF MICONAZOLE AND SULCONAZOLE AGAINST CANDIDA-ALBICANS

被引：0
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作者：
BEGGS, WH
机构：
来源：
BIOCHEMICAL ARCHIVES | 1994年 / 10卷 / 02期
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中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Comparative viable-count and K+-release experiments were designed to establish more definitively the mechanism by which antifungal imidazoles rapidly kill yeast cells of Candida albicans. The drugs selected for study included miconazole, sulconazole, econazole, bifonazole, clotrimazole, and ketoconazole. Results supported the existing hypothesis that the rapid and pronounced lethal activity characteristic of some, but not all, imidazoles is caused by direct physicochemical cell membrane damage.
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页码：117 / 121
页数：5
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