REFLEX EPILEPSY IN THE PAPIO-PAPIO BABOON, PARTICULARLY PHOTOSENSITIVE EPILEPSY

Papio-papio baboons may present two types of reflex paroxysmal manifestations: Myoclonia and generalized seizures are induced by intermittent light stimulation in predisposed animals; this photosensitive epilepsy resembles that observed in some human patients; it involves mainly the cerebral cortex during myoclonia which ave accompanied by EEG paroxysmal discharges, and the mesencephalic reticular formation during seizures; Myoclonia of a different type, never accompanied by EEG paroxysmal discharged and never evolving into seizures, may occur during movement or agitation of predisposed animals; these myoclonia are considered ''non-epileptic'' since they do not involve the cerebral cortex but probably the lower brain stem; they resemble that observed in startle disease or in some human degenerative disorders. The paper demonstrates that these manifestations constitute two different entities with clinical and electrophysiological characteristics as well as pharmacological reactivities completely different one from the other, Their ''epileptic'' or ''non-epileptic'' nature is discussed.