NAD(P)+-NAD(P)H MODELS .85. THE ENZYME/COENZYME/METAL/SUBSTRATE QUATERNARY COMPLEX GENERATED IN THE TRANSITION-STATE OF THE REDUCTION OF BENZOYLFORMATE WITH NAD(P)H MODELS

被引：3
|
作者：
MIKATA, Y [1 ]
MIZUKAMI, K [1 ]
IKEHARA, K [1 ]
机构：
[1] KYOTO UNIV,INST CHEM RES,UJI,KYOTO 611,JAPAN
来源：
TETRAHEDRON LETTERS | 1995年 / 36卷 / 36期
关键词：
D O I：
10.1016/0040-4039(95)01298-V
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Enantioselectivities in the reduction of methyl benzoylformate with NAD(P)H model compounds, N-alpha-methylbenzyl-1-propyl-1,4-dihydronicotinamide (PNPH) and N-benzyl-1-propyl-1,4-dihydronicotinamide (PNBH), in the presence of N-protected amino acids have been studied. The stereoselectivity was perturbed by the amino acids which have a side chain capable of coordinating onto Mg2+.
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页码：6491 / 6494
页数：4
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