CHROMOSOMAL ASSIGNMENT OF THE HUMAN GENE FOR THE CANCER-ASSOCIATED RETINOPATHY PROTEIN (RECOVERIN) TO CHROMOSOME 17P13.1

被引：25

作者：

MCGINNIS, JF

AUSTIN, B

KLISAK, I

HEINZMANN, C

KOJIS, T

SPARKES, RS

BATEMAN, JB

LERIOUS, V

机构：

[1] UNIV CALIF LOS ANGELES,MENTAL RETARDAT RES CTR,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,DEPT MED,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,DEPT OPHTHALMOL,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,JULES STEIN EYE INST,LOS ANGELES,CA 90024

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1995年 / 40卷 / 02期

关键词：

P53; FISH; PHOTORECEPTOR CELL PROTEIN; 23KDA;

D O I：

10.1002/jnr.490400204

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The gene for the mouse recoverin protein (23 kDa photoreceptor-specific protein, S-modulin, or the Cancer-Associated Retinopathy protein) was recently assigned to mouse chromosome 11, closely linked to trp53. In this paper, the human gene for recoverin was localized to human chromosome 17 by Southern analysis of restriction digests of the DNA from mouse/human somatic cell hybrids. Using a 7 kb subclone of the human recoverin gene, a positive fluorescence in situ hyridization signal was demonstrated near the terminus of the short arm of chromosome 17 at position p13.1. The mapping of recoverin to this region of human chromosome 17, which contains a number of cancer-related loci, suggests a possible mechanism by which cancer-associated retinopathy occurs in humans. (C) 1995 Wiley-Liss, Inc.

引用

页码：165 / 168

页数：4

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