ACTION OF ALPHA-MOMORCHARIN, A RIBOSOME-INACTIVATING PROTEIN, ON CULTURED TUMOR-CELL LINES

被引：29
|
作者：
NG, TB
LIU, WK
SZE, SF
YEUNG, HW
机构：
[1] CHINESE UNIV HONG KONG,FAC MED,DEPT ANAT,SHA TIN,HONG KONG
[2] CHINESE UNIV HONG KONG,CHINESE MED MAT RES CTR,SHA TIN,HONG KONG
来源：
GENERAL PHARMACOLOGY | 1994年 / 25卷 / 01期
关键词：
D O I：
10.1016/0306-3623(94)90012-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. alpha-Momorcharin, a glycoprotein isolated from seeds of the bitter gourd, Momordica charantia inhibited incorporation of [H-3]thymidine, [H-3]leucine and [H-3]uridine into P388 (mouse monocyte-macrophage), J774 (Balb/c macrophage), JAR (human placental choriocarcinoma) and sarcoma S180 cell lines. 2. The most potent inhibitory effect was exerted on P388 cells and the smallest effect on sarcoma cells. 3. alpha-Momorcharin also enhanced the tumoricidal effect of mouse macrophages on mouse mastocytomal (P815) cells.
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页码：75 / 77
页数：3
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