CHROMOSOME MAPPING OF MURINE SUSCEPTIBILITY LOCI TO LIVER CARCINOGENESIS

被引：0

作者：

GARIBOLDI, M

MANENTI, G

CANZIAN, F

FALVELLA, FS

PIEROTTI, MA

DELLAPORTA, G

BINELLI, G

DRAGANI, TA

机构：

[1] UNIV MILAN, IST NAZL TUMORI, DIV EXPTL ONCOL A, I-20133 MILAN, ITALY

[2] UNIV MILAN, DEPT GENET & MICROBIOL, I-20133 MILAN, ITALY

来源：

CANCER RESEARCH | 1993年 / 53卷 / 02期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The validity of mouse liver tumors is controversial in the risk assessment of carcinogenicity of chemicals in humans, because mice used in carcinogenicity bioassays are genetically predisposed to liver tumors. The argument could be resolved once liver tumor susceptibility genes have been cloned and their role in liver tumor development elucidated. We performed a genetic linkage analysis to map murine liver tumor susceptibility genes, as a first step toward their identification. An F2 population of 87 urethane-treated male A/J x C3H/He mice was scored with 83 genetic markers. Three regions, localized on chromosomes 7, 8, and 12, were found to contain putative liver tumor susceptibility genes.

引用

页码：209 / 211

页数：3

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