Hypertensive Disorders of Pregnancy Appear Not to Be Associated with Alzheimer's Disease Later in Life

被引：20

作者：

Abheiden, Carolien N. H. ^{[1
]}

van Doornik, Rebecca ^{[1
]}

Aukes, Annet M. ^{[1
]}

van der Flier, Wiesje M. ^{[2
,3
]}

Scheltens, Philip ^{[2
]}

de Groot, Christianne J. M. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Obstet & Gynecol, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, NL-1007 MB Amsterdam, Netherlands

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA | 2015年 / 5卷 / 03期

关键词：

Alzheimer's disease; Magnetic resonance imaging; Preeclampsia; Pregnancy-induced hypertension; Early-onset dementia;

D O I：

10.1159/000439043

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: After hypertensive disorders of pregnancy, more subjective cognitive complaints and white matter lesions are reported compared to women after normal pregnancies. Both have a causal relationship with Alzheimer's disease (AD). Aim: To investigate if women whose pregnancy was complicated by hypertensive disorders have an increased risk of AD. Methods: A case-control study in women with AD from the Alzheimer Center of the VU University Medical Center Amsterdam and women without AD. Paper and telephone surveys were performed. Results: The response rate was 85.2%. No relation between women with (n = 104) and without AD (n = 129) reporting pregnancies complicated by hypertensive disorders (p = 0.11) was found. Women with early-onset AD reported hypertensive disorders of pregnancy more often (p = 0.02) compared to women with late-onset AD. Conclusion: A reported history of hypertensive disorders of pregnancy appears not to be associated with AD later in life. (C) 2015 S. Karger AG, Basel

引用

页码：375 / 385

页数：11

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