THE PERSISTENCE OF SISTER-CHROMATID EXCHANGE FREQUENCIES IN MEN OCCUPATIONALLY EXPOSED TO VINYL-CHLORIDE MONOMER

被引：14
|
作者：
FUCIC, A [1 ]
GARAJVRHOVAC, V [1 ]
DIMITROVIC, B [1 ]
SKARA, M [1 ]
机构：
[1] VINILPLAST MED DEPT, ZADAR, CROATIA
来源：
MUTATION RESEARCH | 1992年 / 281卷 / 02期
关键词：
VINYL CHLORIDE; PERSISTENCE OF SISTER-CHROMATID EXCHANGES; HUMAN;
D O I：
10.1016/0165-7992(92)90047-L
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The persistence of sister-chromatid exchange frequencies in a population occupationally exposed to the well known chemical mutagen vinyl chloride monomer was studied. It was shown that increased values of sister-chromatid exchange frequencies were still present in the lymphocytes of workers who had not been exposed for 8-120 days and retired persons for 5-10 years after exposure. The possible ability of vinyl chloride monomer alkylating metabolities to cause long-lasting damage of the DNA molecule is discussed.
引用
收藏
页码：129 / 132
页数：4
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