EFFECTS OF BENZYLPIPERAZINE DERIVATIVES ON THE NEUROTOXICITY OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE IN RAT-BRAIN

被引：15
|
作者：
HASHIMOTO, K [1 ]
MAEDA, H [1 ]
GOROMARU, T [1 ]
机构：
[1] FUKUYAMA UNIV,FAC PHARM & PHARMACEUT SCI,FUKUYAMA,JAPAN
来源：
BRAIN RESEARCH | 1992年 / 590卷 / 1-2期
关键词：
3,4-METHYLENEDIOXYMETHAMPHETAMINE; NEUROTOXICITY; BENZYLPIPERAZINE; SEROTONIN; PARA-NITROBENZYLPIPERAZINE; PARA-CHLOROBENZYLPIPERAZINE; 1-PIPERONYLPIPERAZINE;
D O I：
10.1016/0006-8993(92)91119-Y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) in rat brain was attenuated significantly by coadministration of several benzylpiperazines (p-nitrobenzylpiperazine, p-chlorobenzylpiperazine and 1-piperonylpiperazine), which were weak inhibitors for [H-3]6-nitroquipazine binding to the 5-hydroxytryptamine (5-HT) transporter in rat brain. These results suggest that these benzylpiperazines may inhibit the MDMA-induced neurotoxicity by a novel neuropharmacological effect other than 5-HT uptake inhibition.
引用
收藏
页码：341 / 344
页数：4
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