NUCLEOTIDE-SEQUENCE OF THE CHINESE-HAMSTER NA+/H+ EXCHANGER NHE1

被引：25
|
作者：
COUNILLON, L [1 ]
POUYSSEGUR, J [1 ]
机构：
[1] UNIV NICE SOPHIA ANTIPOLIS,CNRS,CTR BIOCHIM,PARC VALROSE,F-06108 NICE 2,FRANCE
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1172卷 / 03期
关键词：
NHE1; CDNA CLONING; SEQUENCE COMPARISON; STRUCTURE FUNCTION STUDY;
D O I：
10.1016/0167-4781(93)90228-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have cloned and sequenced the cDNA coding for the Chinese hamster Na+/H+ antiporter expressed in the CCL39 fibroblast cell line. This cDNA contains an open reading frame encoding a protein of 822 amino acids which is homologous to the human NHE1 isoform. Sequence comparison studies show that the first cytoplasmic loop of the transporter is completely different between the two species indicating that the conservation of this domain is not required for the function of the antiporter.
引用
收藏
页码：343 / 345
页数：3
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