Introduction: Non steroidal anti inflammatory drugs (NSAIDs) are among the most prescribed and used drugs, because of their therapeutic efficacy in multiple epidemiological indication. Severity of the bleeding in the case of duodenal ulcer would be different between the group of patients taking NSAIDs and those not taking NSAIDs before bleeding complication. Materials and methods: We propose to study the group of patients admitted for bleeding peptic ulcer (BPU) with NSAIDs and to compare it to the group without NSAIDs. Four hundred and twenty eight patients were admitted during this period for bleeding duodenal ulcer. Results: The NSAID previous hemorrhage was noted in 29.5% of patients (n=126). There was no statistically significant difference between the group taking NSAID (n=126) and NSAIDs negative (n=302) in terms of average age (45.4 vs 45 respectively). There is a clear male predominance compared in the 2 groups. There was no statistically significant difference in terms of average rate of Hte, endoscopic data (seat of the ulcer, stage Forrest, endoscopic hemostasis). The surgery was no more frequent in cases of BPU associated with NSAID Furthermore, patients who used NSAIDs had more frequent initial hemodynamic instability (4 patients vs 1, p=0.01), recurred more frequently (8.7% vs 4%, p=0.04) and there was trend to more death in the group with NSAID. Conclusion: The episode of bleeding from peptic ulcer associated with NSAID use was more severe
