PROPRANOLOL-METHACRYLIC ACID COPOLYMER BINDING INTERACTION

被引：23
|
作者：
LEE, HK
HAJDU, J
MCGOFF, P
机构：
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 02期
关键词：
D O I：
10.1002/jps.2600800220
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The polyanionic form of methacrylic acid:methacrylic acid methyl ester copolymer reacts readily with propranolol.HCI to give a sparingly soluble complex at saturation equilibrium. Propranolol: methacrylic acid copolymer complex is characterized by differential thermal analysis, and IR and UV spectroscopic methods. Propranolol content is found to be 68% in the complex. The value of the Hill coefficient (1.5) indicates that there is a high degree of positive cooperative interaction between propranolol and the polymer.
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页码：178 / 180
页数：3
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