CHOLINESTERASE SENSOR BASED ON ELECTRODE MODIFIED WITH SILVER NANOPARTICLES

被引：0
|
作者：
Shamagsumova, R. V. [1 ]
Piven, E. S. [2 ]
Sitdikov, R. R. [3 ]
Stoikov, I. I. [3 ]
Evtyugin, G. A. [1 ]
Budnikov, H. K. [1 ]
机构：
[1] Kazan Fed Univ, AM Butlerov Inst Chem, Dept Analyt Chem, Kazan, Russia
[2] Kazan Fed Univ, AM Butlerov Inst Chem, Kazan, Russia
[3] Kazan Fed Univ, AM Butlerov Inst Chem, Dept Organ Chem, Kazan, Russia
来源：
UCHENYE ZAPISKI KAZANSKOGO UNIVERSITETA-SERIYA ESTESTVENNYE NAUKI | 2013年 / 155卷 / 02期
关键词：
cholinesterase sensor; biosensor; chemically modified electrodes; inhibition; thiol detection;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A cholinesterase sensor has been developed on the basis of a glassy carbon electrode modified with carbon black and silver nanoparticles and applied for the determination of enzyme substrate and inhibitor. Silver nanoparticles were synthesized by chemical reduction of silver nitrate with macrocyclic ligand containing catechol fragments. The working conditions for the measurement of the signal toward acetylthiocholine and malaoxon were established. Introduction of the silver nanoparticles made it possible to decrease the potential down to 150 mV and improve the sensitivity of the response toward malaoxon in comparison with the analogous biosensors without any modification of the transducer. The developed biosensor makes it possible to determine 2.10(-5) - 2.10(-4) M acetylthiohcoline and 4.10(-10) 4.10(-8) M malaoxon (detection limit is 0.4 nM).
引用
收藏
页码：39 / 50
页数：12
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