METAL CHELATING AMINO-ACIDS IN THE DESIGN OF PEPTIDES AND PROTEINS - SYNTHESIS OF N-ALPHA-FMOC BU(T) PROTECTED AMINO-ACIDS INCORPORATING AMINODIACETIC ACID MOIETY

被引：10

作者：

KAZMIERSKI, WM

机构：

[1] Department of Pharmacognosy, University of Rhode Island, Kingston

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 28期

关键词：

D O I：

10.1016/0040-4039(93)88067-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of Fmoc/Bu(t) protected amino acid chelators 14, 15, 16 and 24 is described. With respect to their Boc/Bzl derivatives, the title compounds offer synthetic advantage: Peptide Ac-Ada(1)-Ala3-Ada(1)-Ala4-Glu-Lys-NH2 was assembled by Solid PPS in 74.2% yield.

引用

页码：4493 / 4496

页数：4

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