COMPARISON OF ACTIVITIES OF FLUOROQUINOLONES IN MURINE MACROPHAGES INFECTED WITH MYCOBACTERIUM-TUBERCULOSIS

被引：28
|
作者：
SKINNER, PS [1 ]
FURNEY, SK [1 ]
KLEINERT, DA [1 ]
ORME, IM [1 ]
机构：
[1] COLORADO STATE UNIV,DEPT MICROBIOL,MYCOBACTERIOL RES LAB,FT COLLINS,CO 80523
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 03期
关键词：
D O I：
10.1128/AAC.39.3.750
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In this study the compounds levofloxacin and sparfloxacin, as well as three experimental compounds (AMQ2, AMQ4, and AMQ5), were compared with isoniazid and rifabutin in terms of their capacity to inhibit the intracellular growth of the drug susceptible Mycobacterium tuberculosis strain Erdman and the isoniazid-resistant katG gene-negative strain 24 within monolayers of mouse bone marrow-derived macrophages. Both levofloxacin and sparfloxacin, as well as compound AMQ4, had substantial activity in this physiologically relevant model, further confirming the potential usefulness of this class of compounds in the therapy of tuberculosis,
引用
收藏
页码：750 / 753
页数：4
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