INCREASED PRODUCTION OF TGF-BETA AND IL-6 BY AGED SPLEEN-CELLS

被引：34
|
作者：
ZHOU, DH
CHREST, FJ
ADLER, W
MUNSTER, A
WINCHURCH, RA
机构：
[1] JOHNS HOPKINS UNIV, CTR ASTHMA & ALLERGY, SCH MED, 5501 HOPKINS BAYVIEW CIRCLE, BALTIMORE, MD 21224 USA
[2] JOHNS HOPKINS UNIV, FRANCIS SCOTT KEY MED CTR, SCH MED, BALTIMORE, MD 21218 USA
[3] NIA, GERONTOL RES CTR, BALTIMORE, MD 21224 USA
来源：
IMMUNOLOGY LETTERS | 1993年 / 36卷 / 01期
关键词：
IMMUNITY; IMMUNOSENESCENCE; CYTOKINE; INTERLEUKIN;
D O I：
10.1016/0165-2478(93)90061-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Aging is accompanied by a progressive decline in immunity in every species that has been studied. Despite its ubiquity, the causes of immunosenescence are unknown. Transforming growth factor beta (TGF-beta) is a cytokine with potent, immunosuppressive properties. Cells from aged mice produce increased levels of TGF-beta in vitro along with similar increases in interleukin 6 (Il-6), a cytokine which is immunosuppressive at elevated concentrations. Il-6 does not upregulate TGF-beta production, but high concentrations of Il-6 increase the percentage of cells expressing the TGF-beta receptor. Increased TGF-beta production and Il-6-induced upregulation of the TGF-beta receptor may be factors contributing to age-associated immunosuppression.
引用
收藏
页码：7 / 12
页数：6
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