EFFECT OF INTRATRACHEALLY ADMINISTERED LINDANE ON ALDRIN AND BENZO(A)PYRENE CONTENTS IN LUNGS OF RATS

被引：1
|
作者：
KHAN, MA [1 ]
MATIN, MA [1 ]
BEG, MU [1 ]
机构：
[1] IND TOXICOL RES CTR,LUCKNOW 226001,UTTAR PRADESH,INDIA
来源：
TOXICOLOGY LETTERS | 1993年 / 69卷 / 01期
关键词：
LINDANE; LUNG; ALDRIN; BENZO(A)PYRENE; HYDROXYLASE;
D O I：
10.1016/0378-4274(93)90146-O
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Pretreatment with lindane resulted in inhibition of benzo(a)pyrene hydroxylase activity in the lungs of rats. The enzyme activity tended to return to normal 5 days after the administration of lindane. Studies with benzo(a)pyrene and aldrin indicated reduced elimination of these compounds from the lungs of lindane-treated animals, suggesting that lindane may alter the clearance of certain substances or compounds from lungs. The delayed clearance of these compounds from lungs may be an indirect effect of lindane related to inhibition of certain metabolizing enzymes.
引用
收藏
页码：63 / 67
页数：5
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