TARGET SEQUENCE RECOGNITION BY THE CALMODULIN SUPERFAMILY - IMPLICATIONS FROM LIGHT-CHAIN BINDING TO THE REGULATORY DOMAIN OF SCALLOP MYOSIN

被引：94
|
作者：
HOUDUSSE, A [1 ]
COHEN, C [1 ]
机构：
[1] BRANDEIS UNIV,ROSENSTIEL BASIC MED SCI RES CTR,WALTHAM,MA 02254
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 23期
关键词：
D O I：
10.1073/pnas.92.23.10644
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Some of the rules for how members of the calmodulin (CaM) superfamily bind to target peptides are revealed by the crystal structure of the regulatory domain of scallop myosin. The structure shows that the IQ motif of the heavy chain in this invertebrate myosin imposes constraints on both the positioning and conformation of the individual lobes of the light chains. In contrast, analysis of the contact residues in the targets bound by Ca2+-CaM reveals how the structure of CaM accommodates a broader range of sequences consonant with this protein's functional diversity.
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页码：10644 / 10647
页数：4
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