QUANTITATIVE CHARACTERIZATION OF ANTIGENS USING MONOCLONAL-ANTIBODY REACTIVITIES

被引：0
|
作者：
DOPAZO, J
TABERNER, A
MOYA, A
机构：
[1] CSIC,CTR INVEST BIOL,UEI FITOPATOL,E-28006 MADRID,SPAIN
[2] UNIV VALENCIA,DEPT GENET,E-46100 VALENCIA,SPAIN
来源：
COMPUTER APPLICATIONS IN THE BIOSCIENCES | 1993年 / 9卷 / 01期
关键词：
D O I：
暂无
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
A multipurpose program that empirically relates antigenic reactivities with monoclonal antibodies (MAbs) to genetic distances is presented. The program uses a set of known genetic pairwise distances to weigh each MAb depending on its capacity to define groups of taxonomically related antigens. This allows highly accurate identification and classification of unknown antigens. Also, the weights obtained constitute a quantitative measure of epitope conservation and can be used for improved vaccine design.
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页码：101 / 107
页数：7
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