DESIGN, STRUCTURE-ACTIVITY AND X-RAY CRYSTALLOGRAPHIC STUDIES OF PSEUDO-SYMMETRICAL NONPEPTIDYL HIV-1 PROTEASE INHIBITORS

被引：7
|
作者：
BABINE, RE [1 ]
ZHANG, N [1 ]
SCHOW, SR [1 ]
XU, ZB [1 ]
BYRN, RA [1 ]
HASTINGS, RC [1 ]
SEMMELHACK, MF [1 ]
WICK, MM [1 ]
KERWAR, SS [1 ]
机构：
[1] AMER CYANAMID CO, DIV MED RES, LEDERLE LABS, EXPLORATORY MED CHEM SECT, PEARL RIVER, NY 10965 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 04期
关键词：
D O I：
10.1016/S0960-894X(01)80159-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new class of nonamino acid derived HIV-1 protease inhibitors of structure 1 are described. Structure activity relationships are discussed in the context of a protein crystal complex.
引用
收藏
页码：583 / 588
页数：6
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