DESIGN, STRUCTURE-ACTIVITY AND X-RAY CRYSTALLOGRAPHIC STUDIES OF PSEUDO-SYMMETRICAL NONPEPTIDYL HIV-1 PROTEASE INHIBITORS

被引：7

作者：

BABINE, RE ^{[1
]}

ZHANG, N ^{[1
]}

SCHOW, SR ^{[1
]}

XU, ZB ^{[1
]}

BYRN, RA ^{[1
]}

HASTINGS, RC ^{[1
]}

SEMMELHACK, MF ^{[1
]}

WICK, MM ^{[1
]}

KERWAR, SS ^{[1
]}

机构：

[1] AMER CYANAMID CO, DIV MED RES, LEDERLE LABS, EXPLORATORY MED CHEM SECT, PEARL RIVER, NY 10965 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)80159-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new class of nonamino acid derived HIV-1 protease inhibitors of structure 1 are described. Structure activity relationships are discussed in the context of a protein crystal complex.

引用

页码：583 / 588

页数：6

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