Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer

被引：3

作者：

Reese, Adam C. ^{[1
]}

Hardin, Jill ^{[2
,3
]}

Cheng, Iona ^{[4
]}

Casey, Graham ^{[5
]}

Witte, John S. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Urol, 1450 3rd St, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Epidemiol & Biostat, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94158 USA

[4] Univ Hawaii, Canc Res Ctr Hawaii, Epidemiol Program, Honolulu, HI 96813 USA

[5] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90033 USA

来源：

PHARMACEUTICALS | 2010年 / 3卷 / 10期

基金：

美国国家卫生研究院;

关键词：

prostatic neoplasms; non-steroidal anti-inflammatory agents; aspirin; genetic variation; single nucleotide polymorphism;

D O I：

10.3390/ph3103127

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Increasing evidence suggests that prostatic inflammation plays a key role in the development of prostate cancer. It remains controversial whether non -steroidal antiinflammatory drugs (NSAIDs) reduce the risk of prostate cancer. Here, we investigate how a previously reported inverse association between NSAID use and the risk of aggressive prostate cancer is modulated by variants in several inflammatory genes. We found that NSAIDs may have differential effects on prostate cancer development, depending on one's genetic makeup. Further study of these inflammatory pathways may clarify the mechanisms through which NSAIDs impact prostate cancer risk.

引用

页码：3127 / 3142

页数：16

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