CHOLINESTERASES IN THE AMYLOID ANGIOPATHY OF ALZHEIMERS-DISEASE

被引：27
|
作者：
MESULAM, M
CARSON, K
PRICE, B
GEULA, C
机构：
[1] BETH ISRAEL HOSP,DIV NEUROSCI & BEHAV NEUROL,BULLARD & DENNY BROWN LAB,BOSTON,MA 02215
[2] OLD DOMINION UNIV,DEPT BIOL SCI,ELECTRON MICROSCOPY LAB,NORFOLK,VA 23508
来源：
ANNALS OF NEUROLOGY | 1992年 / 31卷 / 05期
关键词：
D O I：
10.1002/ana.410310517
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Vessels affected by amyloid angiopathy in patients with Alzheimer's disease also displayed intense acetylcholinesterase and butyrylcholinesterase activity when examined by light and electron microscopy. The enzymatic properties of the vessel-bound cholinesterases were identical to those of the cholinesterases associated with senile plaques and neurofibrillary tangles. This cholinesterase activity is of unknown origin but represents one of the very few features common to all the major pathological markers of Alzheimer's disease.
引用
收藏
页码：565 / 569
页数：5
相关论文
共 50 条
  • [41] AMYLOID, ALUMINUM AND THE ETIOLOGY OF ALZHEIMERS-DISEASE
    STOREY, E
    MASTERS, CL
    [J]. MEDICAL JOURNAL OF AUSTRALIA, 1995, 163 (05) : 256 - 259
  • [42] AMYLOID PROTEIN AS A MARKER IN ALZHEIMERS-DISEASE
    DUYCKAERTS, C
    DELAERE, P
    HAUW, JJ
    [J]. GAZETTE MEDICALE, 1990, 97 (02): : 11 - 11
  • [43] BIOCHEMISTRY OF ALZHEIMERS-DISEASE AMYLOID PLAQUES
    FRASER, PE
    LEVESQUE, L
    MCLACHLAN, DR
    [J]. CLINICAL BIOCHEMISTRY, 1993, 26 (05) : 339 - 349
  • [44] AMYLOID AND ALZHEIMERS-DISEASE - A QUESTION OF SPECIFICITY
    PERRY, EK
    PERRY, R
    [J]. NEUROBIOLOGY OF AGING, 1989, 10 (05) : 473 - 474
  • [45] CEREBELLAR AMYLOID PLAQUES IN ALZHEIMERS-DISEASE
    BRUCHER, JM
    GILLAIN, C
    BARON, H
    [J]. ACTA NEUROLOGICA BELGICA, 1989, 89 (3-4): : 286 - 293
  • [46] CEREBELLAR AMYLOID PLAQUES IN ALZHEIMERS-DISEASE
    COLE, G
    WILLIAMS, P
    ALLDRICK, D
    [J]. CLINICAL NEUROPATHOLOGY, 1988, 7 (04) : 154 - 154
  • [47] THE AMYLOID PEPTIDE PRECURSOR IN ALZHEIMERS-DISEASE
    OCTAVE, JN
    MACQ, AF
    PHILIPPE, B
    [J]. M S-MEDECINE SCIENCES, 1995, 11 (09): : 1251 - 1259
  • [48] MECHANISMS OF CEREBRAL AMYLOID ANGIOPATHY (CAA) IN ALZHEIMERS-DISEASE - SOLUBLE A-BETA PROTEIN IN BRAIN VESSELS
    KALARIA, RN
    PAX, AB
    PERRY, G
    PREMKUMAR, DRD
    [J]. NEUROBIOLOGY OF AGING, 1994, 15 : S51 - S52
  • [49] CHOLINESTERASES WITHIN NEUROFIBRILLARY TANGLES RELATED TO AGE AND ALZHEIMERS-DISEASE
    MESULAM, MM
    MORAN, MA
    [J]. ANNALS OF NEUROLOGY, 1987, 22 (02) : 223 - 228
  • [50] SPECIAL PROPERTIES OF CHOLINESTERASES IN THE CEREBRAL-CORTEX OF ALZHEIMERS-DISEASE
    GEULA, C
    MESULAM, M
    [J]. BRAIN RESEARCH, 1989, 498 (01) : 185 - 189
12345