SYNTHESIS OF [3-(PHOSPHONOMETHOXY)PYRROLIDIN-1-YL] DERIVATIVES OF PYRIMIDINES AND PURINES - ANALOGS OF 2',3'-DIDEOXYNUCLEOTIDES

被引：18

作者：

HARNDEN, MR ^{[1
]}

JARVEST, RL ^{[1
]}

PARRATT, MJ ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT, YEW TREE BOTTOM RD, EPSOM KT18 5XQ, SURREY, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 18期

关键词：

D O I：

10.1039/p19920002259

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrrolidin-1-yl derivatives of pyrimidines and purines, incorporating the phosphonomethoxy group as a phosphate mimic, were prepared as analogues of 2',3'-dideoxynucleotides. The heterocyclic bases uracil, thymine, cytosine, adenine and hypoxanthine were constructed upon the primary amino group of the N-aminopyrrolidine 7, which was prepared by reaction of the dibromide 6 with hydrazine.

引用

页码：2259 / 2263

页数：5

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