VOLUNTARY INTAKE OF ALCOHOL IS ATTENUATED BY IPSAPIRONE IN MICE AND ROLE OF 5-HT1A-RECEPTOR

被引:0
|
作者
CHEN, CC
FUJIWARA, Y
AKIYAMA, K
UJIKE, H
MORIYA, F
OTSUKI, S
机构
[1] OKAYAMA UNIV,SCH MED,DEPT LEGAL MED,OKAYAMA 700,JAPAN
[2] TAIPEI CITY PSYCHIAT CTR,DEPT ADULT PSYCHIAT,TAIPEI,TAIWAN
来源
JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY | 1992年 / 46卷 / 01期
关键词
VOLUNTARY ALCOHOL INTAKE; MICE; IPSAPIRONE; 5-HT1A-RECEPTOR;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Emerging evidences have suggested that the brain serotonin (5-hydroxytryptamine, 5-HT) neurotransmitter system is involved in the compulsive alcohol-seeking behaviors in humans and animal models. The aim of this study is to examine the effect of ipsapirone, which is a specific 5-HT1A agonist with a pyrimidinylpiperazine structure, on alcohol consumption in mice (C57BL/6J) by a voluntary alcohol intake paradigm. When the consumed alcohol was expressed as g/kg B.W., the total 12-day amount was significantly lower in the ipsapirone-treated mice than in the saline-treated mice. However, 5-HT1A receptor binding sites labeled with [H-3]8-OH-DPAT in hippocampal membranes did not differ significantly in either the total number of binding sites (Bmax) or dissociation constant (Kd) between the two groups. The possible mechanism regarding the role of ipsapirone that attenuated the alcohol consumption, and its relationship to the subtyping 5-HT receptors are further discussed.
引用
收藏
页码:197 / 203
页数:7
相关论文
共 50 条
  • [31] 5(10→9)Abeo-ergoline derivatives:: Synthesis, 5-HT1A-receptor affinity and selectivity
    Mantegani, S
    Baumer, L
    Brambilla, E
    Caccia, C
    Fornaretto, MG
    McArthur, RA
    Varasi, M
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1998, 33 (04) : 279 - 292
  • [32] The effect of antiepileptic drugs on 5-HT1A-receptor binding measured by positron emission tomography
    Theodore, WH
    Giovacchini, G
    Bonwetsch, R
    Bagic, A
    Reeves-Tyer, P
    Herscovitch, P
    Carson, RE
    EPILEPSIA, 2006, 47 (03) : 499 - 503
  • [33] MOLECULAR-BIOLOGY OF THE 5-HT1A-RECEPTOR - LOW-STRINGENCY CLONING AND EUKARYOTIC EXPRESSION
    ALBERT, PR
    JOURNAL OF CHEMICAL NEUROANATOMY, 1992, 5 (04) : 283 - 288
  • [34] Pharmacological characterization of MP349, a novel 5-HT1A-receptor antagonist with anxiolytic-like activity, in mice and rats
    Wesolowska, A
    Paluchowska, MH
    Golembiowska, K
    Chojnacka-Wójcik, E
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2003, 55 (04) : 533 - 543
  • [35] 5-HT1A-receptor (5-HT1AR) modulate excitatory and inhibitory neuronal activity within the nucleus tractus solitarii (nTS)
    Ostrowski, Tim Daniel
    Kline, David D.
    FASEB JOURNAL, 2013, 27
  • [36] 5-HT1A-receptor over-expressing mice: Genotype and sex dependent responses to antidepressants in the forced swim-test
    Guenther, Lydia
    Rothe, Julia
    Rex, Andre
    Voigt, Joerg-Peter
    Millan, Mark J.
    Fink, Heidrun
    Bert, Bettina
    NEUROPHARMACOLOGY, 2011, 61 (03) : 433 - 441
  • [37] Ipsapirone suppresses food intake in food-deprived rats by an action at 5-HT1A receptors
    Arkle, M
    Ebenezer, IS
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 408 (03) : 273 - 276
  • [38] SUBCHRONIC TREATMENT WITH ANXIOLYTIC DOSES OF THE 5-HT1A RECEPTOR AGONIST IPSAPIRONE DOES NOT AFFECT 5-HT2 RECEPTOR SENSITIVITY IN THE RAT
    BAUDRIE, V
    DEVRY, J
    BROQUA, P
    SCHMIDT, B
    CHAOULOFF, F
    GLASER, T
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 231 (03) : 395 - 406
  • [39] NEITHER THE 5-HT1A-RECEPTOR NOR THE 5-HT2-RECEPTOR SUBTYPE MEDIATES THE EFFECT OF FLUVOXAMINE, A SELECTIVE SEROTONIN REUPTAKE INHIBITOR, ON FORCED-SWIMMING-INDUCED IMMOBILITY IN MICE
    EGAWA, T
    ICHIMARU, Y
    IMANISHI, T
    SAWA, A
    JAPANESE JOURNAL OF PHARMACOLOGY, 1995, 68 (01): : 71 - 75
  • [40] 5-HT1A-RECEPTOR SUBTYPE MEDIATES THE EFFECT OF FLUVOXAMINE, A SELECTIVE SEROTONIN REUPTAKE INHIBITOR, ON MARBLE-BURYING BEHAVIOR IN MICE
    ICHIMARU, Y
    EGAWA, T
    SAWA, A
    JAPANESE JOURNAL OF PHARMACOLOGY, 1995, 68 (01): : 65 - 70