ALTERED SYNAPTOSOMAL NOREPINEPHRINE UPTAKE OF THE HYPOTHALAMUS IN GENETICALLY-OBESE (OB OB) AND DIABETIC (DB DB) MICE

被引：0
|
作者：
SHIMIZU, H [1 ]
MORI, M [1 ]
KOBAYASHI, I [1 ]
机构：
[1] GUNMA UNIV,SCH MED,DEPT LAB MED,MAEBASHI,GUNMA 371,JAPAN
来源：
NEUROENDOCRINOLOGY LETTERS | 1991年 / 13卷 / 06期
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D O I：
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中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Synaptosomal [H-3]norepinephrine (NE) uptake of hypothalamus was measured in genetically obese (ob/ob) and diabetic (db/db) mice. Synaptosomal [H-3]NE uptake of (ob/ob) mice was significantly decreased compared with that of their lean littermates. Synaptosomal [H-3]NE uptake of db/db mice was also lower than that of lean mice, although the degree of reduction in NE uptake was greater in ob/ob mice. The present study suggests that reduced NE reuptake of hypothalamus may be involved in the hyperphagia of genetically obese and diabetic mice.
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页码：425 / 430
页数：6
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