2'-O,5-DIMETHYLURIDINE - A TOTAL SYNTHESIS AND SINGLE-CRYSTAL X-RAY-DIFFRACTION STUDY

被引：10
|
作者：
LEWIS, AF [1 ]
REVANKAR, GR [1 ]
HOGAN, ME [1 ]
机构：
[1] BAYLOR COLL MED,CTR BIOTECHNOL,THE WOODLANDS,TX 77381
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1993年 / 30卷 / 05期
关键词：
D O I：
10.1002/jhet.5570300522
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for the synthesis of 2'-O,5-dimethyluridine (5) has provided the title compound in a higher yield. Application of a one-pot ribosylation methodology resulted in an efficient, high yield synthesis of 5-methyluridine (ribothymine, 3b). An X-ray diffraction analysis of 5 disclosed the conformation of the sugar moiety of this nucleoside as anti N(3'-endo), g(+).
引用
收藏
页码：1309 / 1315
页数：7
相关论文
共 50 条
  • [31] SINGLE-CRYSTAL X-RAY-DIFFRACTION STUDY OF THE INGAAS-GAASP/GAAS SUPERLATTICE SYSTEM
    JIANG, BL
    SHIMURA, F
    ROZGONYI, GA
    HAMAGUCHI, N
    BEDAIR, SM
    APPLIED PHYSICS LETTERS, 1988, 52 (15) : 1258 - 1260
  • [32] X-RAY-DIFFRACTION STUDY OF THE PHASE-TRANSITION IN A C60 SINGLE-CRYSTAL
    KASATANI, H
    TERAUCHI, H
    HAMANAKA, Y
    NAKASHIMA, S
    PHYSICAL REVIEW B, 1993, 47 (07): : 4022 - 4024
  • [33] SYNCHROTRON X-RAY-DIFFRACTION MEASUREMENTS OF SINGLE-CRYSTAL HYDROGEN TO 26.5 GIGAPASCALS
    MAO, HK
    JEPHCOAT, AP
    HEMLEY, RJ
    FINGER, LW
    ZHA, CS
    HAZEN, RM
    COX, DE
    SCIENCE, 1988, 239 (4844) : 1131 - 1134
  • [34] SINGLE-CRYSTAL X-RAY-DIFFRACTION STUDIES OF OLIGONUCLEOTIDES AND OLIGONUCLEOTIDE DRUG COMPLEXES
    KENNARD, O
    HUNTER, WN
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1991, 30 (10) : 1254 - 1277
  • [35] SYNCHROTRON X-RAY-DIFFRACTION FROM A MICROSCOPIC SINGLE-CRYSTAL UNDER PRESSURE
    SKELTON, EF
    AYERS, JD
    QADRI, SB
    MOULTON, NE
    COOPER, KP
    FINGER, LW
    MAO, HK
    HU, Z
    SCIENCE, 1991, 253 (5024) : 1123 - 1125
  • [36] THE DEVELOPMENT OF A FULL PROFILE ANALYSIS OF SINGLE-CRYSTAL X-RAY-DIFFRACTION DATA
    THOMAS, DJ
    JOURNAL DE PHYSIQUE, 1986, 47 (C-5): : 69 - 73
  • [37] SINGLE-CRYSTAL X-RAY-DIFFRACTION STUDIES OF MATERIALS AT HIGH-TEMPERATURE
    SCHULZ, H
    PROGRESS IN CRYSTAL GROWTH AND CHARACTERIZATION OF MATERIALS, 1987, 14 : 303 - 314
  • [38] SINGLE-CRYSTAL X-RAY-DIFFRACTION STUDY ON STRUCTURAL-CHANGE OF AGGAS2 WITH INCREASING PRESSURE
    ISHIZAWA, N
    KITAHARA, H
    KOMORI, T
    NODA, Y
    MARUMO, F
    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS, 1993, 32 : 171 - 172
  • [39] SINGLE-CRYSTAL X-RAY-DIFFRACTION OF N-H2 AT HIGH-PRESSURE
    HAZEN, RM
    MAO, HK
    FINGER, LW
    HEMLEY, RJ
    PHYSICAL REVIEW B, 1987, 36 (07): : 3944 - 3947
  • [40] THE STRUCTURE OF BAK0.03BIO0.97O3 BY SINGLE-CRYSTAL X-RAY-DIFFRACTION
    CHAILLOUT, C
    CHENAVAS, J
    DURR, J
    MAREZIO, M
    SCHNEEMEYER, L
    PHYSICA C, 1991, 185 : 697 - 698
12345