2'-O,5-DIMETHYLURIDINE - A TOTAL SYNTHESIS AND SINGLE-CRYSTAL X-RAY-DIFFRACTION STUDY

被引：10

作者：

LEWIS, AF ^{[1
]}

REVANKAR, GR ^{[1
]}

HOGAN, ME ^{[1
]}

机构：

[1] BAYLOR COLL MED,CTR BIOTECHNOL,THE WOODLANDS,TX 77381

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1993年 / 30卷 / 05期

关键词：

D O I：

10.1002/jhet.5570300522

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of 2'-O,5-dimethyluridine (5) has provided the title compound in a higher yield. Application of a one-pot ribosylation methodology resulted in an efficient, high yield synthesis of 5-methyluridine (ribothymine, 3b). An X-ray diffraction analysis of 5 disclosed the conformation of the sugar moiety of this nucleoside as anti N(3'-endo), g(+).

引用

页码：1309 / 1315

页数：7

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