THE SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF ENANTIOMERICALLY PURE HYDROXYLATED OXOTREMORINE DERIVATIVES

被引：11
|
作者：
TRYBULSKI, EJ
KRAMSS, RH
MANGANO, RM
BRABANDER, HJ
FRANCISCO, G
机构：
[1] Medical Research Division, American Cyanamid Co., Lederle Labs., Pearl River
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 08期
关键词：
D O I：
10.1016/S0960-894X(00)80539-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and radioligand binding data of optically active hydroxylated oxotremorine derivatives are described. There are significant pharmacological differences between the enantiomers. most notably at the 3- and 4-position of the pyrrolidinone ring. In addition, there appears to be one side of the pyrrolidinone ring that accommodates substitutents better than the other (facial selectivity).
引用
收藏
页码：827 / 832
页数：6
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