DESIGN, SYNTHESIS AND DNA-CLEAVING PROFILES OF HYBRIDS CONTAINING THE NOVEL ENEDIYNE AND NATURALLY-OCCURRING DNA INTERCALATORS

被引:20
|
作者
TOSHIMA, K
OHTA, K
OHASHI, A
NAKAMURA, T
NAKATA, M
MATSUMURA, S
机构
关键词
D O I
10.1039/c39930001525
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The designed hybrids 5-11 containing the DNA cleavable enediyne 4 and naturally occurring DNA intercalators 12-18 cleave DNA effectively under alkaline conditions without any additive; the hybrids 5 and 11 exhibit the strongest DNA-cleaving abilities with the identical high purine base (G>A) selectivities for their DNA-cleavage profiles.
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页码:1525 / 1527
页数:3
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