CLONING AND SEQUENCING OF A GENE ENCODING CARMINOMYCIN 4-O-METHYLTRANSFERASE FROM STREPTOMYCES-PEUCETIUS AND ITS EXPRESSION IN ESCHERICHIA-COLI

被引：55

作者：

MADDURI, K

TORTI, F

COLOMBO, AL

HUTCHINSON, CR

机构：

[1] UNIV WISCONSIN,SCH PHARM,MADISON,WI 53706

[2] UNIV WISCONSIN,DEPT BACTERIOL,MADISON,WI 53706

[3] FARMITALIA CARLO ERBA SPA,DIPARTIMENTO BIOTECNOL,UNITA SCREENING,MILAN,ITALY

来源：

JOURNAL OF BACTERIOLOGY | 1993年 / 175卷 / 12期

关键词：

D O I：

10.1128/JB.175.12.3900-3904.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sequence analysis of a portion of the Streptomyces peucetius daunorubicin biosynthetic gene cluster revealed a complete open reading frame (dnrK) that showed DNA and protein sequence homology to several O-methyltransferases. Expression of dnrK in Streptomyces lividans and Escherichia coli was done to show that this gene codes for carminomycin 4-O-methyltransferase. The deduced carminomycin 4-O-methyltransferase protein shows a conserved nucleotide binding site for its S-adenosyl-L-methionine cofactor.

引用

页码：3900 / 3904

页数：5

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