THE GRADIENT OF BASIC FIBROBLAST GROWTH-FACTOR CONCENTRATION IN HUMAN PANCREATIC-CANCER CELL INVASION

被引：19
|
作者：
HASEGAWA, Y [1 ]
TAKADA, M [1 ]
YAMAMOTO, M [1 ]
SAITOH, Y [1 ]
机构：
[1] KOBE UNIV,SCH MED,DEPT SURG 1,CHUO KU,KOBE 650,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 200卷 / 03期
关键词：
D O I：
10.1006/bbrc.1994.1611
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It has been reported that basic fibroblast growth factor (b-FGF) is overexpressed In human pancreatic cancer cells, and that the overexpressed b-FGF contributes to the disease progression (Yamanaka et al. Cancer Res. 53, 5292-5297, 1993). Pancreatic cancer aggressively invades surrounding tissues by penetrating basement barriers. Thus, effect of b-FGF on pancreatic cancer, cell invasion to Matrigel basement membrane, was studied. The high gradient of b-FGF increased the invasiveness of human pancreatic cancer cells in a dose-dependent manner. Furthermore, the invasiveness of the cells was suppressed by anti-FGF receptor antibody. These results suggest that b-FGF plays an important role in human pancreatic cancer cell invasion to basement membrane. (C) 1994 Academic Press, Inc.
引用
收藏
页码：1435 / 1439
页数：5
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