ANALYSES OF 95 1ST-TRIMESTER SPONTANEOUS-ABORTIONS BY CHORIONIC VILLUS SAMPLING AND KARYOTYPE

被引：62
|
作者：
STROM, CM
GINSBERG, N
APPLEBAUM, M
BOZORGI, N
WHITE, M
CAFFARELLI, M
VERLINSKY, Y
机构：
[1] Department of Obstetrics and Gynecology, Illinois Masonic Medical Center, Reproductive Genetics Institute and Section of Medical Genetics, Chicago, 60657, Illinois
来源：
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 1992年 / 9卷 / 05期
关键词：
CHORIONIC VILLUS SAMPLING; KARYOTYPE; SPONTANEOUS ABORTIONS; 1ST TRIMESTER;
D O I：
10.1007/BF01204052
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Purpose: Our purpose was to determine the incidence of chromosomal aneuploidy in first-trimester pregnancy losses using chorionic villus sampling (CVS). Study Design: All patients presenting for CVS with no fetal cardiac activity were offered CVS. Results: Cytogenetic results were completed in 95 of 96 cases (99%). Eighty-three percent of the karyotypes were aneuploid. The 16 euploid fetuses had no excess of females. Conclusion: CVS is the most reliable method of determining the karyotype of spontaneously aborted fetuses. The incidence of aneuploidy is much greater than in previous reports that analyzed passed products of conception. CVS should be offered to women who present with first-trimester spontaneous abortions.
引用
收藏
页码：458 / 461
页数：4
相关论文
共 50 条
  • [31] 1ST TRIMESTER DIAGNOSIS OF RHO (D) WITH AN IMMUNOFLUORESCENCE TECHNIQUE AFTER CHORIONIC VILLUS SAMPLING
    FUHRMAN, HC
    KLINK, F
    GRZEJSZCZYK, G
    VOSSBERG, A
    POSCHMANN, A
    GEUSENDAM, G
    FROSTERISKENIUS, U
    SCHWINGER, E
    [J]. PRENATAL DIAGNOSIS, 1987, 7 (01) : 17 - 21
  • [32] CHORIONIC VILLUS SAMPLING AFTER 1ST TRIMESTER DIAGNOSIS OF FETAL CYSTIC HYGROMA COLLI
    PONS, JC
    DIALLO, AA
    EYDOUX, P
    RAIS, S
    DOUMERC, S
    FRYDMAN, R
    PAPIERNIK, E
    [J]. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1989, 33 (02): : 141 - 146
  • [33] PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN AND CHORIONIC-GONADOTROPIN LEVELS AFTER 1ST-TRIMESTER ABORTIONS
    MANDELIN, M
    RUTANEN, EM
    HEIKINHEIMO, M
    JALANKO, H
    SEPPALA, M
    [J]. OBSTETRICS AND GYNECOLOGY, 1978, 52 (03): : 314 - 317
  • [34] FAILURE TO DIAGNOSE LESCH-NYHAN SYNDROME BY 1ST TRIMESTER CHORIONIC VILLUS SAMPLING
    GRUBER, A
    ZEITUNE, M
    FEJGIN, M
    [J]. PRENATAL DIAGNOSIS, 1989, 9 (06) : 452 - 453
  • [35] HISTOLOGICAL EXAMINATION OF 1ST TRIMESTER SPONTANEOUS-ABORTIONS - THE IMPACT OF MATERNO-EMBRYONIC INTERFACE FEATURES
    JAUNIAUX, E
    HUSTIN, J
    [J]. HISTOPATHOLOGY, 1992, 21 (05) : 409 - 414
  • [36] VISUALIZATION OF PEROXISOMES AND PLASMALOGENS IN 1ST TRIMESTER CHORIONIC VILLUS
    ROELS, F
    VERDONCK, V
    PAUWELS, M
    FOULON, W
    LISSENS, W
    LIEBAERS, I
    [J]. JOURNAL OF INHERITED METABOLIC DISEASE, 1987, 10 : 233 - 235
  • [37] SERUM-PROTEINS IN HUMAN CHORIONIC VILLI IN THE 1ST TRIMESTER OF PREGNANCY - AN IMMUNOHISTOCHEMICAL STUDY ON NORMAL TISSUE AND TISSUE OBTAINED FROM SPONTANEOUS-ABORTIONS
    MASSI, G
    COLI, A
    MARANO, G
    [J]. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1986, 23 (1-2): : 13 - 23
  • [38] EXPECTANT MANAGEMENT OF 1ST-TRIMESTER SPONTANEOUS-ABORTION
    NIELSEN, S
    HAHLIN, M
    [J]. LANCET, 1995, 345 (8942): : 84 - 86
  • [39] 1ST TRIMESTER PRENATAL-DIAGNOSIS BY CHORIONIC VILLUS SAMPLING - THE JOHANNESBURG EXPERIENCE WITH 48 CASES
    ROSENDORFF, J
    JACOBSON, MJ
    MORRIS, D
    RAMSAY, M
    LANE, AB
    BERNSTEIN, R
    [J]. SOUTH AFRICAN MEDICAL JOURNAL, 1989, 75 (01): : 15 - 17
  • [40] PRENATAL CYTOGENETIC DIAGNOSIS AFTER TRANS-ABDOMINAL CHORIONIC VILLUS SAMPLING IN THE 1ST TRIMESTER
    THERKELSEN, AJ
    JENSEN, PKA
    HERTZ, JM
    SMIDTJENSEN, S
    HAHNEMANN, N
    [J]. PRENATAL DIAGNOSIS, 1988, 8 (01) : 19 - 31
12345