THE INFLUENCE OF PROLINE-CONTAINED PEPTIDES PRO-GLY-PRO AND ITS METABOLITES GLY-PRO AND PRO-GLY ON GASTRIC ACID SECRETION IN RATS

被引：0
|
作者：
Traverse, G. M.
Tsvireko, S. M.
Ananevich, O. I.
Zuzyna, L. S.
机构：
来源：
WORLD OF MEDICINE AND BIOLOGY | 2010年 / 25卷 / 02期
关键词：
glyprolines; gastric acid secretion;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
It was established that all investigated glyprolines suppressed basal gastric acid secretion (GAS) in rats. Pro-Gly-Pro and Gly-Pro also inhibited GAS stimulated by carbachol and histamine. Pro-Gly did not influence on GAS stimulated by carbachol and histamine. The one of mechanisms of influence of glyprolines on GAS is stimulation of nitric oxide releasing, which leads to inhibition of basal and stimulated GAS. We conclude that glyprolines in the future can be used in medical practice for treatment of diseases associated with hypersecretion of acid.
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页码：189 / 193
页数：6
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