HEAT-STABILITY OF A RECOMBINANT-DNA HEPATITIS-B VACCINE

被引：38
|
作者：
VANDAMME, P [1 ]
CRAMM, M [1 ]
SAFARY, A [1 ]
VANDEPAPELIERE, P [1 ]
MEHEUS, A [1 ]
机构：
[1] SMITHKLINE BEECHAM BIOL,B-1330 RIXENSART,BELGIUM
来源：
VACCINE | 1992年 / 10卷 / 06期
关键词：
HEAT STABILITY; RECOMBINANT DNA; HEPATITIS-B;
D O I：
10.1016/0264-410X(92)90064-Q
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The heat stability of a recombinant DNA hepatitis B vaccine was studied in healthy adult volunteers. When compared with vaccine stored at 4-degrees-C, heating of the vaccine for 1 week at 45-degrees-C or for 1 month at 37-degrees-C did not alter the reactogenicity or the ability of the vaccine to elicit antibody titres considered to be protective. These results have signifcance in situations where the cold chain is broken, as can happen in countries where proper storage and transport facilities are not always available.
引用
收藏
页码：366 / 367
页数：2
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