INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE BY 6-PHOSPHOGLUCONATE IN RAT-LIVER

被引：0
|
作者：
KALOYIANNI, M
机构：
[1] Laboratory of Animal Physiology, Science School, Aristotelian University of Thessaloniki, Thessaloniki
来源：
EXPERIENTIA | 1991年 / 47卷 / 03期
关键词：
RAT LIVER; PHOSPHOENOLPYRUVATE CARBOXYKINASE; 6-PHOSPHOGLUCONATE;
D O I：
10.1007/BF01958149
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Various concentrations of 6-phosphogluconate inhibit rat liver phosphoenolpyruvate carboxykinase activity. 0.04mM 6-phosphogluconate, which is the concentration found in vivo, caused a 50% inhibition of 6-phosphoenolpyruvate carboxykinase activity. 6-Phosphogluconate lowered the V(max) of the enzyme and increased the concentration of phosphoenolpyruvate required to achieve one-half of the maximum velocity. The role of 6-phosphogluconate as a regulator of the coordination of fluxes through three metabolic pathways is discussed.
引用
收藏
页码：248 / 249
页数：2
相关论文
共 50 条
12345