BEHAVIORAL AND ELECTROENCEPHALOGRAPHIC EFFECTS OF TITYUS-SERRULATUS SCORPION-VENOM IN RATS

被引：17
|
作者：
SANDOVAL, MRL [1 ]
DORCE, VAC [1 ]
机构：
[1] BUTANTAN INST,PHARMACOL LAB,BR-05504 SAO PAULO,SP,BRAZIL
来源：
TOXICON | 1993年 / 31卷 / 02期
基金：
巴西圣保罗研究基金会;
关键词：
D O I：
10.1016/0041-0101(93)90287-S
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This study was designed to investigate the convulsant effects of T. serrulatus scorpion venom in rats. Pretreatment of rats with venom increased the minimum convulsant dose of picrotoxin, impaired convulsion generalization and displaced to the left the dose-response curve for picrotoxin. It also decreased the intensity but prolonged the duration of seizures caused by pentylenetetrazol injection. Microinjection of the venom into the dorsal hippocampus induced behavioural alterations and epileptiform waves in the EEG. Venom also altered the threshold for, and intensity of, convulsions induced in different experimental models of epilepsy. Different fractions of the venom may be responsible for these different effects. Therefore, purification of venom toxins is necessary for the complete understanding of the present results.
引用
收藏
页码：205 / 212
页数：8
相关论文
共 50 条
  • [31] PURIFICATION OF THE MAIN BETA-TOXIN FROM TITYUS-SERRULATUS SCORPION-VENOM USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    CEARD, B
    DELIMA, ME
    BOUGIS, PE
    MARTINEAUCLAIRE, MF
    TOXICON, 1992, 30 (01) : 105 - 110
  • [32] ACUTE GASTRIC-MUCOSAL INJURY INDUCED BY TOXINS FROM TITYUS-SERRULATUS SCORPION-VENOM - A NOVEL EXPERIMENTAL-MODEL IN THE RAT
    CUNHAMELO, JR
    TOPPA, NH
    MARTINS, P
    COLARES, CN
    CASTRO, YS
    FREIREMAIA, L
    TOXICON, 1991, 29 (11) : 1395 - 1401
  • [33] EFFECTS AND MECHANISM OF ACTION OF TITYUS-SERRULATUS VENOM ON SKELETAL-MUSCLE
    BRAZIL, OV
    NEDER, AC
    CORRADO, AP
    PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1973, 5 (02): : 137 - 150
  • [34] Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venom
    Barao, A. A. S.
    Nencioni, A. L. A.
    Dorce, V. A. C.
    JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, 2008, 14 (02): : 322 - 337
  • [35] EFFECTS OF FRACTIONS PURIFIED FROM VENOM OF THE SCORPION TITYUS-SERRULATUS ON THE ELECTRICAL-ACTIVITY OF THE RABBIT VAGUS NERVE
    MILL, JG
    ARANTES, EC
    GIGLIO, JR
    RICCIOPONETO, F
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1985, 18 (5-6) : A758 - A758
  • [36] Tityus serrulatus Scorpion Venom and Toxins: An Overview
    Cologna, Camila T.
    Marcussi, Silvana
    Giglio, Jose R.
    Soares, Andreimar M.
    Arantes, Eliane C.
    PROTEIN AND PEPTIDE LETTERS, 2009, 16 (08): : 920 - 932
  • [37] Body distribution of Tityus serrulatus scorpion venom in mice and effects of scorpion antivenom
    Revelo, MP
    Bambirra, EA
    Ferreira, AP
    Diniz, CR
    ChavezOlortegui, C
    TOXICON, 1996, 34 (10) : 1119 - 1125
  • [38] PRESYNAPTIC EFFECTS INDUCED BY BRAZILIAN SCORPION-VENOM (TITYUS-SERRULATUS) - INCREASED ENDOGENOUS NORADRENALIN RELEASE AND FACILITATION OF ADRENERGIC NEUROTRANSMITTER RELEASE INDUCED BY NERVE-STIMULATION
    ADLERGRASCHINSK.E
    DEALMEIDA, AP
    LANGER, SZ
    DINIZ, SR
    MEDICINA-BUENOS AIRES, 1974, 34 (06) : 628 - 629
  • [39] EFFECT OF IODINATED VENOM FROM THE SCORPION TITYUS-SERRULATUS ON ARTERIAL-PRESSURE AND URINARY FLOW IN DOGS
    MACHADO, RP
    CARDINI, JF
    HENEINE, LGD
    HENEINE, IF
    ALZAMORA, F
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1986, 19 (4-5) : A537 - A537
  • [40] PURIFICATION AND STRUCTURAL CHARACTERIZATION OF A POTENT K-CHANNEL BLOCKER FROM SCORPION TITYUS-SERRULATUS VENOM
    ROGOWSKI, RS
    COLLINS, JH
    BLAUSTEIN, MP
    FASEB JOURNAL, 1992, 6 (01): : A250 - A250
12345