SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF 2-NITRO-3-SUBSTITUTED-AMINO BENZO[B]THIOPHENES AND THEIR 5-CHLORO-DERIVATIVES

被引：0
|
作者：
GUERRERA, F
SALERNO, L
SARVA, MC
SIRACUSA, MA
LAMARTINA, L
CARUSO, A
CUTULI, V
机构：
[1] UNIV PALERMO,DIPARTIMENTO CHIM & TECHNOL FARMACEUT,I-90123 PALERMO,ITALY
[2] UNIV CATANIA,FAC MED,IST FARMACOL,I-95125 CATANIA,ITALY
来源：
FARMACO | 1992年 / 47卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This paper reports the synthesis and the pharmacological evaluation of some 2-nitro-3-N-phenylamino-benzo[b]-thiophenes and 5-chloro derivatives of the most active of these compounds; in addition, some 5-chloro derivatives of 2-nitro-3-alkylen- or phenylen-diamino-benzo[b]thiophenes previously synthesized were prepared. These compounds were screened for analgesic, antiexudative and antiinflammatory activities related to phenylbutazone. Nitration of 5-chloro-3-bromo-benzo[b]thiophene was also studied.
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页码：1149 / 1160
页数：12
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