Outcome of Epstein-Barr virus-associated primary breast cancer

被引:15
|
作者
Mazouni, Chafika [1 ,2 ]
Fina, Frederic [1 ]
Romain, Sylvie [1 ]
Ouafik, L'Houcine [1 ]
Bonnier, Pascal [3 ]
Martin, Pierre-Marie [3 ]
机构
[1] Northern Fac Med, Transfer Lab Biol Oncol, Publ Assistance Hosp Marseille, Marseille, France
[2] Inst Gustave Roussy, Dept Gen Surg, Canc Campus,114 Edouard Vaillant St, F-94805 Villejuif, France
[3] Beauregard Hosp, Inst Surg & Gynecol & Breast Oncol, Marseille, France
关键词
breast cancer; Epstein-Barr virus; molecular types; survival;
D O I
10.3892/mco.2014.459
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The presence of the Epstein-Barr-virus (EBV) has been reported to be a pathogenic factor in breast cancer (BC). We previously demonstrated the aggressiveness of EBV-positive BC. The purpose of the present study was to evaluate the effect of EBV on the prognosis of BC according to the BC phenotype. A total of 117 patients with primary BC previously tested for the presence of EBV were evaluated. The presence of the virus was evaluated in breast specimens using quantitative PCR (qPCR). Disease-free survival (DFS) and overall survival (OS) were evaluated for 4 molecular subtypes, namely luminal A and B (lumA and lumB, respectively), human epidermal growth factor receptor 2 (HER2) and triple-negative (TN) subtypes and according to the EBV status. EBV positivity was observed in 32.5% of the cases. TN, HER2 and lumB tumours were more frequent among EBV-BC cases (P=0.02). The DFS rates were different between BC subtypes (P=0.002), but the differences were not statistically significant when the cases were stratified according to the EBV status (P=0.08 for EBV-negative and 0.06 for EBV-positive cases). The OS rates were similar for BC subtypes (P=0.50) and when the cases were stratified according to the EBV status (P=0.16 and P= 0.67 for EBV-positive and -negative cases, respectively). EBV was not associated with DFS or OS, in contrast to BC phenotypes, tumour size or nodal status. Therefore, EBV positivity was found to exert no effect on survival, despite its association with aggressive BC phenotypes.
引用
收藏
页码:295 / 298
页数:4
相关论文
共 50 条
  • [21] STUDIES ON EPSTEIN-BARR VIRUS-ASSOCIATED ANTIGENS
    ERNBERG, I
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1975, 254 : 516 - 522
  • [22] The Microenvironment in Epstein-Barr Virus-Associated Malignancies
    Tan, Geok Wee
    Visser, Lydia
    Tan, Lu Ping
    van den Berg, Anke
    Diepstra, Arjan
    PATHOGENS, 2018, 7 (02)
  • [23] Epstein-Barr virus-associated lymphoproliferative disorders
    Grywalska, Ewelina
    Markowicz, Justyna
    Grabarczyk, Piotr
    Pasiarski, Marcin
    Rolinski, Jacek
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2013, 67 : 481 - 490
  • [24] IMMUNOBIOLOGY OF EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOMAS
    ROCHFORD, R
    MOSIER, DE
    CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1994, 71 (03): : 256 - 259
  • [25] Epstein-Barr virus-associated gastric carcinoma
    Adachi, Y
    Yoh, R
    Konishi, J
    Iso, Y
    Matsumata, T
    Kasai, T
    Hashimoto, H
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 1996, 23 (03) : 207 - 210
  • [26] Epstein-Barr virus-associated diseases in humans
    Kawa, K
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2000, 71 (02) : 108 - 117
  • [27] Epstein-Barr virus-associated lymphoproliferations and lymphomas
    Anagnostopoulos, I.
    Joehrens, K.
    PATHOLOGE, 2013, 34 (03): : 262 - 271
  • [28] Epstein-Barr virus-associated nephrotic syndrome
    Mikhalkova, Deana
    Khanna, Sahil
    Vaidya, Rakhee
    Sethi, Sanjeev
    Hogan, Marie C.
    CLINICAL KIDNEY JOURNAL, 2012, 5 (01): : 50 - 52
  • [29] Neuroimaging of Epstein-Barr virus-associated encephalitis
    Reis-Melo, Ana
    Rosario, Marta
    Melo, Claudia
    Sousa, Raquel
    ANALES DE PEDIATRIA, 2020, 92 (01): : 53 - 54
  • [30] EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS
    PURTILO, DT
    STROBACH, RS
    OKANO, M
    DAVIS, JR
    LABORATORY INVESTIGATION, 1992, 67 (01) : 5 - 23