OPIATE BINDING-SITES IN MUCOSA OF PIG SMALL-INTESTINE

Opiates such as morphine have profound antidiarrheal and constipating actions due in part to their ability to modify intestinal ion transport. This study was undertaken to examine the presence of opiate binding sites in the porcine distal jejunum, a gut segment analogous to the human ileum. Specific binding sites for the tritiated, mu-selective opioid agonist [D-Ala2, N-Me-Phe4, Gly5-ol]enkephalin (DAMGO) were localized to the basal portion of villous and crypt cells of the intestinal epithelium by receptor autoradiography. These binding sites may represent enkephalin receptors capable of modulating active electrolyte transport.